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Iowa State: The Cyclones and Hawkeyes renew their rivalry in Week 2 The Cyclones h…

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21 Iowa, where he has won at least eight games in four of the last five seasons prior to 2026. Iowa still has a competition at quarterback, but running back Kamari Moulton and tight end DJ Vonnahme are key returning players who will help ease the eventual starter in.

We'll go over the latest Iowa State vs. Iowa betting odds at DraftKings Sportsbook and provide our best plays for the Week 2 showdown with help from the SportsLine Projection Model. Iowa State kicked off the Jimmy Rogers era with a 38-10 win over Southeast Missouri State while Iowa dominated Northern Illinois 40-0.

Bet on Week 2 college football, including Iowa State vs. Iowa, at DraftKings and get $200 in bonus bets when you spend $5+: The Cyclones are bringing in an entirely new team after Matt Campbell took most of the 2025 group with him to Penn State .

The model simulates every FBS game 10,000 times. It is on a 33-20 run on top-rated CFB money-line picks on betting sites since the 2024 season, and it has been upgraded for the 2026 season to even better factor in the transfer portal.

KEY POINTS

  • The Cyclones and Hawkeyes renew their rivalry in Week 2 The Cyclones have won three of the last four meetings between these teams, and Iowa's 2023 triumph was officially vacated by the NCAA.
  • Bet on Week 2 college football, including Iowa State vs. Rogers comes to Ames after a 6-6 campaign at Washington State in 2025.
  • The Cy-Hawk rivalry is renewed on Saturday as the Iowa State Cyclones will try to continue their recent dominance over the Iowa Hawkeyes , this time with a new head coach, when these rivals meet at Kinnick Stadium in Iowa City, Iowa.
  • There are some holdovers for the Cyclones who will be stepping into bigger roles, with running back Aiden Flora and receiver Dominic Overby shining in Week 1.